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KMID : 0984920090110010081
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Journal of Skin Barrier Research
2009 Volume.11 No. 1 p.81 ~ p.96
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Hormones and Skin barrier
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Kim Byung-Soo
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Abstract
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The cutaneous permeability barrier resides in the outermost layer of the epidermis, which is composed of 2 compartments including corneocytes and lipid-enriched, intercellular matrix. Deterioration in the permeability barrier stimulates a coordinated, lipid synthetic and secretory response in the underlying epidermis that leads to rapid restoration of barrier homeostasis. Yet, little is known about the regulation of epidermal barrier homeostasis by circulating hormones or other biologic response modifiers. Hormones are chemicals released by cells that affect cells in other parts of the body. It is a chemical messenger transporting a signal from one cell to another. The focus of this current paper is to review the clinical and investigative literatures over the past decade regarding the physiological effect of such hormones on structural and physical characteristics of skin barrier function. In particular, steroid sex hormones including estrogens and androgens’ role in maintaining epidermal function, skin integrity and permeability will be discussed.
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KEYWORD
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Permeability barrier, Hormones, Estrogens, Androgens
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